Foxc2 transcription factor: a newly described regulator of angiogenesis
Identifieur interne : 006B07 ( Main/Exploration ); précédent : 006B06; suivant : 006B08Foxc2 transcription factor: a newly described regulator of angiogenesis
Auteurs : Tsutomu KumeSource :
- Trends in cardiovascular medicine [ 1050-1738 ] ; 2008.
Abstract
Angiogenesis is a critical process to form new blood vessels from pre-existing vessels under physiological and pathological conditions and involves cellular and morphological changes such as endothelial cell proliferation, migration, and vascular tube formation. Despite evidence that angiogenic factors, including vascular endothelial growth factor (VEGF) and Notch, control various aspects of angiogenesis, the molecular mechanisms underlying gene regulation in blood vessels and surrounding tissues are not fully understood. Importantly, recent studies demonstrate that Forkhead transcription factor Foxc2 directly regulates expression of various genes involved in angiogenesis,
Url:
DOI: 10.1016/j.tcm.2008.11.003
PubMed: 19185813
PubMed Central: 2674371
Affiliations:
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